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Understand how Medicare Part B and Part C cover Keytruda, an immunotherapy for cancer, and what your out-of-pocket costs might be. Learn about deductibles, coinsurance, and supplemental insurance options.

Receiving a cancer diagnosis can be overwhelming, and navigating the complexities of treatment and insurance can add to that stress. If you or a loved one are facing cancer and have Medicare, you might be wondering about coverage for newer, life-saving treatments like Keytruda (pembrolizumab). This powerful immunotherapy drug has shown significant success in treating various cancers, including melanoma and lung cancer. Let's break down how Medicare covers Keytruda and what you can expect in terms of costs.
Keytruda is a type of immunotherapy that works by helping your immune system fight cancer. It's a prescription medication that is administered through an intravenous (IV) infusion. Unlike traditional chemotherapy, which directly attacks cancer cells, Keytruda essentially 'releases the brakes' on your immune system, allowing it to recognize and destroy cancer cells more effectively. It has been FDA-approved for a growing list of cancers, making it a vital treatment option for many patients.
The good news for Medicare beneficiaries is that Keytruda infusions are generally covered under Medicare Part B. Part B is the part of Original Medicare that helps pay for outpatient services, including doctor's visits, preventive services, and outpatient drugs like Keytruda when administered in a doctor's office or clinic. Because Keytruda is given via infusion by a licensed medical professional, it falls under the category of an outpatient prescription drug covered by Part B.
It's important to distinguish this from other parts of Medicare. Medicare Part A primarily covers inpatient hospital stays. While cancer drugs administered during an inpatient hospital stay would be covered under Part A, Keytruda infusions typically occur in an outpatient setting.
Medicare Part D, which covers prescription drugs you take at home, usually does not cover Keytruda. Since Keytruda is administered via infusion by a healthcare provider, it's not a take-home medication. Therefore, even if you have a Part D plan, Keytruda coverage will likely fall under Part B.
While Medicare Part B covers Keytruda, you will still have some out-of-pocket expenses. Here's what to expect:
You must first meet your annual Medicare Part B deductible. For 2024, this deductible is $240. Until this amount is paid, Medicare will not cover the costs of Part B services or medications.
Once you have met your Part B deductible, you will typically pay 20% of the Medicare-approved amount for the Keytruda infusion. Medicare will pay the remaining 80%.
Without any supplemental insurance, the cost of Keytruda can be substantial. For instance, a single 200-milligram (mg) dose can cost over $11,000 without insurance. With Medicare Part B, after meeting the deductible, your share of the cost would be 20% of the Medicare-approved rate for that dose. This can still amount to thousands of dollars per infusion, depending on the dosage and frequency.
Imagine Mrs. Sharma, a 70-year-old Medicare beneficiary, starts Keytruda treatment for lung cancer. Her first infusion is in March after she has already paid her $240 Part B deductible for the year. The Medicare-approved amount for her infusion is $10,000. Mrs. Sharma's responsibility would be 20% of $10,000, which is $2,000. Medicare would cover the remaining $8,000. She will need to pay this $2,000 every 3-6 weeks, depending on her treatment schedule, until her treatment is complete.
Medicare Part C, also known as Medicare Advantage, is offered by private insurance companies approved by Medicare. These plans must cover everything that Original Medicare (Part A and Part B) covers, but they often include additional benefits like prescription drug coverage, dental, vision, and hearing.
Coverage for Keytruda under Medicare Advantage plans can vary. Most Part C plans will cover Keytruda, as it's typically administered as an outpatient service covered by Part B. However, your specific costs will depend on the plan's deductible, copayments, and coinsurance structure.
According to manufacturer data, a significant portion of Medicare Advantage members have had minimal to no out-of-pocket costs for Keytruda. Approximately 38% reported no out-of-pocket expenses, while 80% of those who did incur costs paid between $0.01 and $925 after meeting their plan's deductible. This highlights the potential financial advantage of certain Medicare Advantage plans for beneficiaries needing expensive treatments like Keytruda.
Medigap policies, also known as Medicare Supplement Insurance, can help fill the gaps in Original Medicare coverage, including deductibles and coinsurance.
If you have a Medigap plan that covers the Part B deductible and coinsurance, your out-of-pocket costs for Keytruda could be significantly lower, potentially even zero in some cases.
Navigating cancer treatment and insurance can be complex. It's essential to have a clear understanding of your coverage and potential costs. Here’s what you should do:
A: Medicare covers Keytruda for the specific types of cancer that the FDA has approved it for. Your doctor will determine if Keytruda is an appropriate treatment for your specific diagnosis.
A: The frequency of Keytruda infusions can vary depending on the type of cancer being treated and your individual treatment plan. It is typically administered every 3 to 6 weeks.
A: No, Keytruda must be administered by a licensed healthcare professional in an infusion center or a doctor's office. It cannot be taken at home.
A: If your Medicare Advantage plan does not provide adequate coverage, you may be able to switch to Original Medicare with a Medigap plan during the annual enrollment period, provided you are eligible. It's always best to review your plan options annually.
Dealing with cancer is challenging enough. Understanding your Medicare coverage for treatments like Keytruda can provide much-needed clarity and peace of mind. Always consult with your healthcare team and insurance provider to ensure you have the most accurate and personalized information regarding your treatment and costs.
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