Actidase A Tablet

Actidase A tablet is used to relieve acute pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults. It contains aceclofenac, which blocks pain-causing chemicals in the body, and serratiopeptidase, which helps reduce swelling and break down harmful tissue. Together, they help manage pain, fever, and inflammation.

You should not take Actidase A tablet if you have allergies to its ingredients, a history of stomach ulcers or bleeding, severe heart, kidney, or liver problems, or are pregnant. Common side effects include dizziness, nausea, stomach pain, and allergic reactions. Always take the tablet as directed, with or without food, and at the same time each day for best results.

This medicine may interact with several other medications, including blood thinners, blood pressure medications, heart medications, lithium, methotrexate, and certain antibiotics or antidepressants. These combinations can raise the risk of bleeding, kidney issues, or other serious side effects. Let your doctor know about all medications or supplements you’re taking.

Avoid Actidase A tablet during pregnancy and breastfeeding unless your doctor advises otherwise. Do not drive if you feel dizzy or sleepy after taking it. Avoid alcohol while on this medicine.

If you miss a dose, take it as soon as you remember, but don’t double up. In case of overdose, seek medical help immediately.

Dosage

Missed a Dose

If you missed a dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Overdose

• If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
• Taking too much of this medicine can be dangerous. It may cause symptoms like headache, nausea, vomiting, stomach pain, dizziness, ringing in the ears, sleepiness, confusion, or even fainting and seizures. In severe cases, it can lead to kidney failure, liver damage, or trouble breathing. Always follow the prescribed dose and seek medical help right away if too much is taken.

Mode of Action

How Does It Work?

• Aceclofenac works by blocking a substance in the body (called COX-2) that helps make chemicals called prostaglandins. These chemicals cause pain, swelling, and fever. By reducing them, aceclofenac helps relieve pain, reduce inflammation, and lower fever.
• Serratiopeptidase may reduce inflammation by affecting the movement and adhesion of immune cells. It may also help clear blood clots and plaque in arteries by breaking down harmful tissue without damaging healthy cells.

Directions for Use

• The tablet can be taken with or without food and swallowed whole with water.
• Take it at the same time for better results.

Precautions and Warnings

Pregnancy

Can I take Actidase A tablet during pregnancy?

Actidase A tablet should not be used during pregnancy. If you are pregnant, stop taking the medication and consult your doctor.

Breast Feeding

Can I take Actidase A tablet while breastfeeding?

It’s not known if Actidase A tablet passes into breast milk, but animal studies showed very little transfer. To be safe, it should be avoided during pregnancy and breastfeeding unless your doctor says it’s necessary.

Driving

Can I drive if I have consumed Actidase A tablet?

Taking Actidase A tablet may cause side effects, such as dizziness, sleepiness, tiredness, or blurred vision. If you feel any of these, do not drive or use machines until you feel better.

Alcohol

Can I consume alcohol with Actidase A tablet?

No, Alcohol consumption with Actidase A tablet is not recommended.

Other General Warnings

Talk to your doctor if

• You take other painkillers like aspirin or ibuprofen, or medicines for high blood pressure, such as ACE inhibitors.
• You take water pills (diuretics), heart medicines like digoxin, or lithium for mental health.
• You take methotrexate, mifepristone, steroids, blood thinners (like warfarin or clopidogrel), certain antibiotics (like quinolones), antidepressants, transplant drugs (like ciclosporin or tacrolimus), or zidovudine for HIV.
• You take diabetic medications; aceclofenac may affect your blood sugar levels. Watch for signs of low or high blood sugar.

Contraindications

• If you are allergic to aceclofenac, serratiopeptidase or any other ingredients of the Actidase A tablet.
• If you have a current or repeated history of stomach ulcers or bleeding.
• If you've ever had breathing problems, a runny nose, swelling (like angioedema), or skin rashes (like hives) after taking painkillers like ibuprofen, aspirin, or other NSAIDs.
• If you have active bleeding or a condition that makes you bleed easily, this medicine is not safe for you.
• If you have renal or hepatic diseases.
• If you have severe heart failure, heart disease, poor circulation in the legs or arms, or a history of stroke, this medicine may not be suitable for you.
• If you’ve had stomach bleeding or a hole in your stomach while using other NSAIDs before.
• If you are pregnant.

Side effects

• Dizziness
• Upset stomach
• Abdominal pain
• Nausea
• Diarrhoea
• Vomiting
• Allergic reactions

Interactions

Interactions with other medicines

• If administered along with Warfarin, Clopidogrel or Aspirin as well as with other natural remedies such as garlic, fish oil and turmeric, there may be an increased risk of bleeding or bruising.
• Medicines for high blood pressure or water pills may not work as well and can increase the risk of kidney problems, especially in elderly or dehydrated patients.
• Heart medications like digoxin may accumulate in the body and exacerbate heart problems.
• Combining with lithium, methotrexate, or transplant medicines can increase side effects, particularly on the kidneys.
• Using Actidase A tablet within 8–12 days after mifepristone may reduce its effectiveness.
• Steroids, blood thinners, antidepressants, and certain antibiotics can raise the risk of bleeding, stomach issues, or seizures.
• Zidovudine (used in HIV treatment) may increase the risk of bleeding problems.
• Diabetes medicines may need dose adjustments as aceclofenac could affect blood sugar levels.

Storage and disposal

• Store in a cool, dry place, away from direct sunlight.
• Keep it out of reach of children and pets.

Frequently Asked Questions (FAQs)

Can I stop taking the medication once I feel better?

No. Continue taking the Actidase A tablet as prescribed, even if you feel well. Discuss your current health condition with your doctor so that they can provide guidance on treatment.

Can Actidase A tablet be given to children?

No, Actidase A tablet is not meant for use in children and adolescents. Consult your doctor for the treatment of acute pain and inflammation in children.

Can I take Actidase A tablet without food?

Take Actidase A tablet with food. During mealtime is ideal, preferably in the morning and evening. This will help to protect your stomach from side effects such as indigestion and stomach irritation.