Calcigen D3 Capsule

Calcigen D3 Capsule is a therapeutic and nutritional supplement that contains cholecalciferol, commonly known as Vitamin D3. It is a fat-soluble vitamin that plays an indispensable role in maintaining calcium and phosphate homeostasis in the human body. Adequate levels of Vitamin D3 are essential for proper growth, development, and mineralisation of bones and teeth, as well as for the functioning of muscles, the cardiovascular system, and the immune system.

When taken orally, cholecalciferol undergoes a two-step activation process in the body. It is first metabolised in the liver to 25-hydroxyvitamin D (calcidiol), which serves as the major circulating form and an indicator of Vitamin D status. This intermediate is then further hydroxylated in the kidneys to form 1,25-dihydroxyvitamin D (calcitriol), the biologically active hormone.

Calcitriol acts by binding to specific Vitamin D receptors located in various tissues, particularly in the intestines, kidneys, and bones. Its primary physiological effect is to enhance the intestinal absorption of calcium and phosphate, reduce renal calcium excretion, and promote bone mineralisation and remodelling. It also regulates parathyroid hormone secretion, thereby preventing secondary hyperparathyroidism and maintaining stable serum calcium concentrations.

Vitamin D deficiency is associated with a spectrum of disorders, including rickets in children, osteomalacia in adults, osteoporosis, muscle weakness, hypocalcemia, and increased fracture risk. Modern lifestyles with reduced outdoor activity, heavy use of sunscreens, darker skin pigmentation, advanced age, and certain medical conditions such as chronic kidney disease, malabsorption syndromes, celiac disease, and inflammatory bowel disease contribute to widespread deficiency. Calcigen D3 Capsule serves as an effective means of restoring and maintaining optimal Vitamin D levels in such individuals.

Calcigen D3 Capsule may cause mild side effects like constipation, increased blood calcium or urine calcium levels, vomiting, and nausea, which typically resolve on their own. Consult your doctor if side effects persist or if you have an allergy to it. Pregnant and breastfeeding women should seek medical advice before use, as Calcigen D3 Capsule can pass into breast milk.

Caution is advised for those with hypercalcemia, renal impairment, heart diseases, kidney stones, or hypervitaminosis D.

Dosage

Missed a Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Taking more than the prescribed dose can cause vitamin D toxicity, leading to hypercalcemia. Symptoms include nausea, vomiting, excessive thirst, frequent urination, confusion, and irregular heartbeat. Seek immediate medical attention in case of overdose.

Mode of Action

How Does It Work?

After being ingested, Calcigen D3 (cholecalciferol) is absorbed from the intestine and converted in the liver to 25-hydroxyvitamin D. It is then converted in the kidneys to its active form, 1,25-dihydroxyvitamin D (calcitriol). This active form boosts the absorption of calcium and phosphate from the intestines, reduces their excretion in urine, and regulates bone remodelling. By maintaining sufficient calcium levels, it prevents bone weakening, supports muscle contraction, and ensures proper nerve transmission.

Directions for Use

• Take Calcigen D3 Capsule as advised by your doctor.
• You should not consume vitamin supplements more than the stated recommended daily dose.

Precautions and Warnings

Other General Warnings

Talk to your doctor if

• You have any existing medical condition, you are on other medications, supplements or following any complementary or integrative health approaches.
• You should not take Calcigen D3 Capsule if you are allergic to any of its components.
• You have any planned surgery or operation. You may be asked to stop taking these products at least 2-3 weeks ahead of the procedure.
• Dietary supplements are intended to supplement the diets of some people and should not be a substitute for a well-balanced, varied diet and a healthy lifestyle.

Contraindications

• You are allergic to vitamin D3 or any ingredient of the capsule.
• You have high blood calcium levels (hypercalcemia).
• You have high levels of vitamin D in your body (hypervitaminosis D).
• You have kidney stones or a history of frequent kidney stones.
• You suffer from severe kidney impairment.
• You have certain heart conditions where calcium levels must be controlled.

Side effects

Calcigen D3 Capsules are usually well-tolerated, but in some cases, side effects may occur, especially with high doses or prolonged use:

• Constipation
• Nausea and vomiting
• Headache
• Stomach pain
• Increased blood calcium levels (hypercalcemia)
• Increased calcium in urine (hypercalciuria)
• Kidney stone formation (rare, with excessive use)
• Fatigue or confusion (in case of very high calcium levels)

Interactions

Interactions with other medicines

• Steroids such as prednisolone may reduce the effectiveness of Vitamin D when taken together with Calcigen D3 Capsules.
• Anticonvulsants including phenytoin, carbamazepine, and barbiturates may increase the breakdown of Vitamin D in the body, thereby lowering its levels.
• Diuretics, particularly thiazide diuretics, may raise calcium levels in the blood when used along with Calcigen D3 Capsules.
• Antacids that contain aluminum or magnesium may increase the risk of toxicity if they are used for a prolonged period with Calcigen D3 Capsules.
• Digoxin and other cardiac glycosides may increase the risk of irregular heartbeat if calcium levels become too high due to Vitamin D supplementation.
• Cholestyramine, a cholesterol-lowering drug, may interfere with the absorption of Vitamin D, reducing its effectiveness.

Storage and disposal

• Store Calcigen D3 Capsules in a clean and dry place.
• Keep away from kids & pets

Frequently Asked Questions (FAQs)

Which foods are a good source of vitamin D?

The best source of vitamin D is sunlight. Vitamin D is formed under our skin when we are exposed to the sun. Very few food products are a good source of vitamin D such as cod liver oil, cheese, egg yolk, etc. Sun exposure from 10 am to 3 pm at least twice a week for 10-30 minutes can help you prevent vitamin D deficiency.

Why should one take vitamin D?

Vitamin D is crucial for calcium absorption, bone health, immune support, and mood regulation. Many people, especially in areas with limited sunlight, may not get enough vitamin D naturally. Deficiency can cause weak bones, muscle weakness, and increased infection risk. Supplementing with vitamin D is often necessary, especially in winter or for those with certain health conditions.

Can I take Calcigen D3 Capsule if I am pregnant?

Calcigen D3 Capsule should be taken under medical supervision by a pregnant woman.