Doxin 10mg Capsule

Doxin is an FDA-approved medication used to treat Major Depressive Disorder. It is prescribed to treat patients who have Insomnia (difficulty sleeping). It also helps treat other conditions such as depression, anxiety, panic attacks by lightning and relieving the mood.

It is available in capsules, topical formulation and oral formulation. Depression appears as a result of a chemical imbalance and a lack of neurotransmitters in the brain. Doxin contains Doxepin as an active ingredient.

It works by increasing the activity of hormones in the brain, which regulate mood, emotions and behaviour by stimulating positive thoughts and feelings in the Person. Doxepin belongs to the class of tricyclic antidepressants. Further, Doxin helps in treating conditions such as skin pruritus.

Topical creams of Doxin work as a local anaesthetic in managing pain and have been useful in treating urethral irritation and dysuria. It also helps in reducing pain by increasing the uptake of feel-good hormones (serotonin) and gives the individual momentary relief. The duration of this medicine and the dose varies among individuals depending on the condition and severity it is being used for.

You should not take more doses than prescribed by your doctor. This medicine is not meant for children. The use of Doxin 10mg without proper prescription by a doctor can cause serious health issues.

Dosage

Overdose

Overdose of Doxin tablets can be fatal. If you happen to take too many Doxin tablets, reach out to the nearest hospital as soon as possible. Establish and maintain airways to ensure adequate oxygenation and respiratory function. Monitor the cardiac function and vital signs(pulse and blood pressure). Symptoms of overdose may include feeling restless or agitated, increased heartbeats, excessive sweating, extreme drowsiness, feeling of passing out, slow movements, seizure or coma.

Missed a Dose

If you have missed a dose of the Doxin tablet, then take it as soon as you remember. There should be a gap of at least six hours between two doses. If it is almost time for the next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.

Mode of Action

How Does It Work?

Doxepin is in the tricyclic antidepressants class of medicine. These agents work by increasing the concentration of the neurotransmitters norepinephrine and serotonin in the brain. Serotonin is a chemical messenger. Doxepin blocks the reuptake of serotonin into the neurons, and thus more serotonin is available, thereby relieving the brain and helping in calming the mood of an individual. Doxin also displays antagonistic properties (stops the action of other substances) in the central nervous system by blocking the following receptors: histamine,alpha-1 adrenergic, and muscarinic. Doxin has H1 and H2 histamine receptor blocking actions, which explains the antipruritic(class of medicine used to relieve itching) effect of Doxepin.

Directions for Use

• Take the Doxin 10mg tablet as a whole with a glass of water or as directed by your doctor.
• Swallow it as a whole. Do not crush, chew or break it.
• It can be taken with or without food.
• The dosage and duration depend on the disease of the individual, the patient’s age and medical history.
• Doxin tablets can cause dependency and thus should be taken with proper prescriptions.

Precautions and Warnings

Pregnancy

Can I take Doxin tablets during pregnancy?

Doxin is unsafe for pregnant women. It poses a risk to the developing foetus. It may cause hearing difficulties and other developmental drawbacks in the infant. The doctor will prescribe this injection only if the benefits outweigh the risks.

Breast Feeding

Can I take Doxin tablets while breastfeeding?

No, the use of Doxin tablets should be avoided as its contents are known to pass into human milk and can cause respiratory distress in infants.

Driving

Can I drive if I have taken the Doxin tablet?

Use of heavy machinery and driving should be avoided as these tablets can cause central nervous system depression and thus may aid sedation and drowsiness. Thus, the use of heavy machinery and driving should be avoided as it requires complete mental alertness.

Alcohol

Can I consume alcohol with the Doxin tablet?

No, alcohol should be avoided as Doxin tablets can cause central nervous depression. And with the synergistic effect of alcohol, severe side effects can be caused.

Other General Warnings

Talk to your doctor if

• You have been consuming alcohol with the medication.
• You are taking any other medication at present, including medication you may buy without a prescription.
• You are planning to have a child, or if you become pregnant while taking this medication.
• You think the medication is not working and want to change the dosage without consulting your doctor. Even when the medication is used as recommended, it may cause emotional and/or physical dependence.
• You want to discontinue treatment in a careful and safe manner. Discontinuation symptoms such as seizures or respiratory distress can occur if the medication is abruptly discontinued. Proper discontinuation will help to decrease the possibility of withdrawal reactions.
• You have a history of any other mental or mood problems (e.g., depression), alcohol dependency or other substance abuse or dependence.
• You are in poor health, overweight, or are experiencing abnormal muscle movements.

Contraindications

• If you are allergic to Doxepin or any other ingredients of the tablet Doxin 10mg.
• If you have a history of seizure disorder or conditions predisposing to seizures (e.g. brain damage, epilepsy).
• If you are taking medication for any skin infections, such as ketoconazole and itraconazole, it may cause a hypersensitivity reaction(avoid using the tablet for at least 14 days).
• If you suffer from diabetes or have bleeding tendencies, bradycardia ( slow heartbeat), recent, decompensated heart failure, electrolyte disturbances (e.g. hypokalaemia), metabolic disease.
• If you have undergone recent heart surgeries.
• If you are taking MAO inhibitors, which are also used to treat depression. There should be a minimum gap of 14 days between the onset of the medication.
• If you are suffering from renal or liver problems, it may lead to hepatic failure or renal impairment.
• If you are pregnant and lactating.

Side effects

• Increased heart rate
• Blurred vision
• Constipation
• Difficulty in urination
• Dryness in mouth
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Weight gain

Interactions

Interactions with other medicines

• Do not take this tablet if you are already taking another medication such as linezolid, i.e.Monoamine Oxidase Inhibitors( MAO), as it may enhance the effect of the tablet and can cause severe complications.
• Oral anticoagulants (e.g. warfarin), antiplatelet agents (e.g. ticlopidine, aspirin, dipyridamole), antipsychotics, and NSAIDs increases bleeding tendencies.
• Other antidepressants (e.g. other SSRIs) increases the risk of seizures, as they can cause a condition known as serotonin syndrome.
• Enhanced hypoglycemic effect of antidiabetic agents, so if you are a diabetic, you should consult the doctor before taking the medication.

Interactions with food items

• No research was conducted to prove any interaction of the drug with food. However, if you feel any reactions on your skin or body after taking the medication, consult your doctor immediately.

Storage and disposal

Store it at 20-25°C temperature and protect it from light and moisture and out of the reach of pets and children. Keep the capsules in their packing away from light and moisture. It should be safely kept in such a place so that children and pets cannot reach it. Leftover medicine should be disposed of safely, not to be consumed accidentally by someone.

Frequently Asked Questions (FAQs)

Can I take Doxin tablets if I am suffering from skin infections?

You should avoid taking Doxin tablets if you are taking medications for skin rashes or fungal infections, as it can cause hypersensitivity reactions. You should consult a doctor.

Can I take Doxin tablets without a prescription?

No, Doxin tablets cannot be taken without a prescription.

Can I take Doxin tablets for a headache?

Doxin tablets cannot be used for headaches. One should consult a doctor.