Axinim Tablets

Axinim Tablets contain a combination of Nimesulide and Paracetamol. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that primarily acts by inhibiting the synthesis of prostaglandins, which are chemical mediators involved in pain, inflammation, and fever. By reducing prostaglandin production, Nimesulide helps to alleviate pain and reduce inflammatory responses in the body.

Paracetamol, also known as acetaminophen, is an analgesic and antipyretic. Its exact mechanism of action is not fully understood but is believed to involve inhibition of prostaglandin synthesis in the central nervous system, leading to pain relief and a reduction in fever. It acts on the thermoregulatory center in the brain, helping to lower elevated body temperature.

This combination is typically prescribed for the short-term management of various painful and inflammatory conditions, such as acute pain, musculoskeletal pain, and fever associated with inflammatory processes. It is important to use this medication as directed by a healthcare professional and for the shortest duration necessary due to potential side effects.

Dosage

Overdose

• Overdose of this medicine may result in serious liver damage.
• Other symptoms include nausea, vomiting, stomach discomforts, stomach bleed, skin rash, fever and chills
• In case of an overdose, contact your doctor immediately or visit the nearest hospital

Missed a Dose

• If you missed any dose of medicine, take it as soon as you remember
• If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule
• Do not take a double dose of medicine to compensate the missed one

Mode of Action

How Does It Work?

• There are some chemicals in the body called prostaglandins
• These are substances that cause pain, swelling and fever
• This medicine blocks the production of these prostaglandins, thus temporarily controlling fever or pain
• It acts on the area of the brain which is responsible for controlling temperature. Thus, it helps in controlling the fever

Directions for Use

This medicine should be swallowed whole with an adequate amount of water. It can be taken after food. Use for a short duration only; prolonged use is not recommended.

Precautions and Warnings

Pregnancy

Can I take Axinim Tablet during pregnancy?

This medicine should not be used if you are in the last three months of pregnancy Also, if you are a woman planning to conceive, this medicine can hamper your fertility. Hence it should be avoided by such women. If taken during pregnancy, it can damage the heart or kidney of the foetus or delay your delivery.

Breast Feeding

Can I take Axinim Tablet while breastfeeding?

It is advised not to use this medicine if you are breastfeeding.

Driving

Can I drive if I have consumed Axinim Tablet?

You may experience drowsiness and sleepiness after taking this medicine. Thus, it is advised not to drive after taking this medicine.

Alcohol

Can I consume alcohol with Axinim Tablet?

It is advisable to avoid the consumption of alcohol during the treatment, as it may worsen your liver problems. If you are regularly drinking, then do not take this medicine.

Other General Warnings

Talk to your doctor if

• You experience loss of appetite, nausea, stomach pain and weakness. These could be signs of serious liver damage
• You develop black tarry stools or vomit blood, immediately stop the medicine
• You are an elderly, chances of side effects increases
• You are suffering from any liver or kidney or heart disease
• You have a history of stomach or intestine ulcers
• You are expected to go through any upcoming surgery
• Taking this medicine for long is not advised as it can increase risk of heart disease or stomach bleeds

Contraindications

• If you are allergic to paracetamol, nimesulide, other anti-inflammatory medicines (aspirin) or any of the ingredient of this medicine
• If you have a history of liver damage induced by anti-inflammatory medicines like (Nimesulide)
• If you have existing or history of stomach bleeding, ulcer and inflammation of stomach lining
• If you have problems related to blood clotting and bleeding disorders
• If you have impaired liver or kidney function
• If you have serious heart failure problem
• If you are an alcoholic or drug addict
• Children under 12 years of age
• If you are suffering from symptoms of flu-like fever, chills, shivering
• If you are pregnant or breastfeeding

Side effects

• Nausea
• Vomiting
• Loose stools
• Stomach or intestine ulcers
• Redness of skin
• Allergic symptoms like breathlessness, swelling of face and lips, eyes
• Increased liver enzymes

Interactions

Interactions with other medicines

• No drug interaction reports are available for this combination. However, as this medicine contains Paracetamol & Nimesulide, any interactions seen with these two components when taken alone may occur with this combination
• You may experience stomach bleeding and ulcers if used along with steroids
• This medicine may interfere with working of blood thinners like Warfarin
• Do not take this medicine along with vomiting medicines like Domperidone and Metoclopramide
• Medicines used to treat high blood pressure like water pill and ‎captopril
• Medicines used for mental problems like Lithium, Phenytoin and Phenobarbital
• Medicine used to treat a certain type of cancer or arthritis-like Methotrexate
• Medicine used to modify immune system during organ transplant like cyclosporin
• Medicine used to treat gout-like probenecid
• Medicines used to treat infections like Chloramphenicol and Rifampicin

Storage and disposal

Storage and disposal

• Store it in a cool and dry place and protected from moisture
• Keep it out of reach of the children

Frequently Asked Questions (FAQs)

Can I take this medicine for six months?

No, prolonged use of this medicine can be detrimental for your health Use of this medicine is meant only for short relief of pain Do not use it for more than 15 days Use for a prolonged period may result in stomach and intestine ulcers and increased risk of heart disease

My child has toothache, can I give Axinim Tablet to him?

No, never give this to your child. This medicine is not meant for children as it can cause liver damage in them.