Pangraf 1 Capsule

Pangraf Capsule is an immunosuppressant medication used to prevent organ rejection in patients undergoing kidney, heart, or liver transplants. Its active ingredient is tacrolimus, which belongs to the class of immunosuppressants. This medication works by reducing the immune response, preventing immune cells from attacking the transplanted organ.

It is essential to use this medicine under the supervision of a specialist doctor experienced in treating organ transplant patients. If you have an infection or are prone to infections, be sure to inform your doctor, as this medication can weaken your immune system.

Dosage

Overdose

An overdose of Pangraf Capsule can lead to tremors, headache, nausea, vomiting, skin reaction and changes in the levels of certain enzymes or parameters (creatinine or blood urea nitrogen). If you have taken too much of this medicine, see your doctor or contact your nearest hospital emergency department immediately.

Missed a Dose

Do not take a double dose of this medicine to make up for forgotten individual doses. If you have forgotten to take Pangraf Capsules, wait until it is time for the next dose and then continue as before.

Mode of Action

How Does It Work?

When a person receives an organ the immune system of the body perceives it as a foreign (non-self) and tries to reject it by attacking the tissues of the transplanted organ. Pangraf Capsule is used is to suppress your body’s immune response enabling your body to accept the transplanted organ.

Directions for Use

• Pangraf Capsule should be taken as prescribed by your doctor.
• You should take this medicine preferably on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.

Precautions and Warnings

Pregnancy

Can I take Pangraf Capsule during pregnancy?

Tell your doctor if you are pregnant or may be pregnant before taking this medicine.

Breast Feeding

Can I take Pangraf Capsule while breastfeeding?

Pangraf Capsule passes into the breastmilk. Therefore, you should not breastfeed whilst receive this medicine. Tell your doctor if you are breastfeeding.

Driving

Can I drive if I have consumed Pangraf Capsule?

Pangraf Capsule may cause visual and neurological disturbances. Avoid driving if you are affected.

Alcohol

Can I consume alcohol with Pangraf Capsule?

Pangraf Capsule may produce side effects such as visual disturbance and neurological disturbances, alcohol can further aggravate this. Hence, you should avoid consuming alcohol while taking this capsule.

Other General Warnings

Talk to your doctor if

• You have liver problems or have or had a disease that may have to affect your liver.
• You are experiencing strong abdominal pain sometimes accompanied by other symptoms, such as chills, fever, nausea or vomiting.
• You have had diarrhoea for more than a day.
• You have an upcoming vaccination schedule.
• You should tell your doctor before taking any herbal preparations especially St. John’s wort (Hypericum perforatum).
• During the initial days of treatment, you may be asked to perform various routine test (heart function, blood, urine, etc) to check the best effective dose for you.
• You should limit your sun exposure while taking this medicine by wearing protective clothing and wearing appropriate sunscreen.

Contraindications

• If you are allergic to tacrolimus or any ingredients of Pangraf Capsule.
• If you are allergic to certain antibiotics which belongs to the class of macrolide antibiotics (e.g. erythromycin, clarithromycin, josamycin).

Side effects

• Headache
• Shakiness
• Increased blood sugar level
• Lack of sleep
• Blurred vision
• Sensitivity to light
• Ringing sound in ears
• Raised blood pressure
• Diarrhoea
• Nausea

Interactions

Interactions with other medicines

• Some medicines can affect the way Pangraf Capsule works or this medicine itself can affect the action of other medicines taken at the same time.
• Tell your doctor about all the medicines you are currently taking, recently taken or might take to avoid any possible interactions.
• In particular, if you are taking antibiotics, anti-viral, anti-fungal, anti-HIV, medicines for stomach ulcers, acid reflux, vomiting, nausea, irregular heart rhythm, high blood pressure any hormonal preparation, medicines acting on the brain, potassium-containing supplements or diuretics.

Interactions with food items

Avoid consuming grapefruit containing products.

Storage and disposal

• Store this medicine at room temperature, away from sunlight and moisture.
• Keep this medicine out of the reach and sight of children and pets.

Frequently Asked Questions (FAQs)

What are the uses of Pangraf Capsule?

Pangraf Capsule is an immunosuppressive medicine. It is used for preventing organ rejection in organ transplant recipients (liver, kidney & heart).

Will Pangraf Capsule cause tremors?

Yes, this medicine can cause tremors as a side effect, however, not everyone gets them.

When should I take Pangraf Capsule?

You should take this medicine preferably on an empty stomach one hour before a meal or 2-3 hours after a meal.