Reziz Forte 37.5/750mg Strip Of 10 Tablets

Reziz Forte 37.5/750mg is a combination medicine of Suphadoxine and Pyrimethamine to treat malaria.

Dosage

Overdose

• In case of overdose, symptoms like dizziness, nausea, and somnolence may occur. Therefore, you should contact your doctor immediately or visit the nearest hospital

Missed a Dose

If you forget to take a dose, take it as soon as you remember. If the next dose is approaching, skip the missing dose. Instead, use your next dose at the same time every day. Do not take two tablets at once.

Mode of Action

How Does It Work?

Pyrimethamine belongs to a class named anti-parasitic, and it works by selectively inhibiting the plasmodial form of dihydrofolate reductase, which reduces the production of folic acid essential for nucleic acid production in the malarial parasite. Similarly, sulfadoxine also helps inhibit the enzyme dihydropteroate synthetase, an enzyme essential for the production of folic acid, which stops the malarial parasites from multiplying.

Directions for Use

• Take this tablet for the dose and duration prescribed by your physician
• Do not break, chew or crush this tablet
• Swallow the tablet with a glass of water

Precautions and Warnings

Pregnancy

Can I take Reziz Forte tablets during pregnancy?

Reziz Forte tablet is unsafe during pregnancy as animal studies have shown definite evidence of abortion or foetal malformation. Therefore, it should only be used when the benefits outweigh the risk to the fetus.

Breast Feeding

Are Reziz Forte tablets safe to use while breastfeeding?

Pyrimethamine is excreted in blood and should be avoided during the duration of treatment.

Driving

Can I drive if I have taken Reziz Forte tablets?

No studies on the effects on driving ability have been performed. However, some may experience adverse effects like dizziness or convulsions, so caution is advised.

Alcohol

Can I consume alcohol with a Reziz Forte tablet?

Caution is advised when consuming alcohol with Reziz Forte tablet.

Other General Warnings

Talk to your doctor if

• You have seizures
• You have crystalluria
• You have anaemia
• You have folate deficiency
• You are galactose intolerant
• You have renal or hepatic impairment
• You are taking other prescription or non-prescription medication
• You are taking herbal supplements, nutritional supplements, vitamins or minerals

Contraindications

• Megaloblastic anaemia
• Infants less than 2 months of age

Side effects

• Fever
• Anaemia
• Leucopenia/Thrombocytopenia
• Headache
• Dizziness
• Vomiting
• Nausea
• Colic or buccal ulceration
• Increased sensitivity of the skin to light
• Irritation or soreness of the tongue
• Skin rash
• Loss of appetite

Interactions

Interactions with other medicines

• Reziz Forte tablet in patients taking folate inhibitors may further depress folate metabolism
• Pyrimethamine with trimethoprim/sulphonamide combination may result in megaloblastic anaemia
• Concurrent administration of methotrexate and pyrimethamine to children with central nervous system leukaemia may result and increase the risk of convulsions
• When given with other antimalarial medicines increases the risk of seizures
• Concurrent administration of lorazepam and daraprim may induce hepatotoxicity
• The presence of antacid salt or anti-diarrhoeal agent like kaolin reduced the absorption of pyrimethamine
• Co-administration of sulfadoxine and insulin increases the risk to hypoglycaemia

Storage and disposal

Keep it in a cool and dry place away from sunlight and moisture Keep the medication away from the reach of children and pets Do not flush the unneeded or expired tablets Talk to your doctor or pharmacist about the safe way of discarding the tablets

Frequently Asked Questions (FAQs)

What is malaria, and how is it caused?

Malaria is a disease caused by the Plasmodium parasite transmitted by the bite of infected mosquitoes.

How long will I have to take the Reziz Forte tablet?

You may need to take this tablet for the duration required to cure the malarial infection; however, the duration also depends on your condition and your body's response to the tablets.

How many times a day should I take this tablet?

You should take this tablet as advised by your doctor, do not take more than the recommended dose per day as it may increase the risk of adverse effects and overdose.

Can I stop taking Reziz Forte tablets when I feel better?

Do not stop taking Reziz Forte tablet, complete the full course of medication even if you feel better.