Tenlimac M 500 Tablet

Tenlimac M is a combination of two medicines, namely teneligliptin and metformin hydrochloride. The combination helps control the sugar level in patients with type 2 diabetes mellitius in which a single medicine may not be effective.

Dosage

Overdose

In case of overdose, reach the nearest doctor or hospital immediately to use supportive measures such as removal of the medicine that is unabsorbed from the bowels.

Missed a Dose

Try not to skip any dose, if missed, take the missed dose when you remember this. If it is time near to your next dose, you should skip the missed dose.

Mode of Action

How Does It Work?

Teneligliptin works by inhibiting the DPP-4 enzyme from producing DPP-4 protein. DPP-4 enzyme degrades incretins, a group of hormones that slows down the production of glucose, increasing the level of insulin. Metformin helps your body to tolerate the insulin that your body produces, reduces the sugar that your liver produces, therefore, decreases the sugar amount your intestines absorb.

Directions for Use

The dosage of Tenlimac M is based on the advice of your physician. Do not crush, break or chew the tablet. Take it whole with a glass of water.

Precautions and Warnings

Pregnancy

Can I take Tenlimac M during pregnancy?

Safety data are not available. You should consult your health adviser.

Breast Feeding

Can I take Tenlimac M while breastfeeding?

You need to consult your health adviser as safety in nursing mothers is not established.

Driving

Can I drive if I have consumed Tenlimac M?

If your blood sugar level is high or low, it can impact your driving ability. If you are experiencing low sugar level, it is advised not to drive.

Alcohol

Can I consume alcohol with Tenlimac M?

Alcohol intake is not recommended while taking this medicine as it can cause low blood sugar.

Other General Warnings

Talk to your doctor if

• You are suffering from kidney disease
• You are suffering from liver disease
• You have allergy to teneligliptin or other gliptins
• You have allergy to metformin
• You have congestive heart failure
• You have history of bowel obstruction, abdominal surgery
• You have cardiac arrythmias
• You have pituatary gland insufficiency

Contraindications

• Kidney problems
• Type 1 diabetic patients
• Hypersensitivity to teneligliptin or any other ingredient of the medicine
• Heart or liver failure
• Severe infection
• Severe ketosis
• Metabolic acidosis
• History of bowel obstruction
• History of abdominal surgery surgery
• Severe trauma
• Diabetic coma or history of diabetic coma

Side effects

• Diarrhoea
• Constipation
• Hypoglycaemia
• Upset stomach
• Nausea
• Protein loss in urine
• Ketones in urine
• Gastric polyps
• Stomatitis
• Flatulence
• Increased amylase levels

Interactions

Interactions with other medicines

• Furosemide increases the concentration of metformin in plasma and blood. Metformin decreases the AUC and Cmax of furosemide
• Nifedipine enhances the metformin absorption
• Metformin may cause suboptimal absorption of oral vitamin B12
• The urine and blood glucose of patient needs to be monitored when taking Danazol with Tenlimac M
• Cationic medicines e.g, amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, or vancomycin, may decrease metformin excretion from kidneys and cause lactic acidosis
• Tenlimac M should be used with caution with medicines that enhance the blood glucose lowering effect e.g., β blockers, MAO inhibitors
• Tenlimac M should be used carefully with medicines that lower the blood glucose lowering effect like steroids, thyroid hormones, etc

Other general Interactions

• Kidney problems
• Allergies
• Heart or liver failure
• Severe infection
• Metabolic acidosis

Storage and disposal

Store at Store at 25 degrees Celsius. Do not store under direct sunlight or heat or moisture. Keep away from children. Dispose as per directions of your pharmacist, do not flush in drain.

Frequently Asked Questions (FAQs)

Can I use the medicine if I have a renal impairment?

No, you should not use this medicine if you have moderate or severe renal impairment.

Can I use the medicine if I have liver failure disease?

Tenlimac M is not recommended for patients having evidence of liver failure.

Can Tenlimac M make my sugar level too low?

Yes, and it can make your sugar level too low i.e., hypoglycaemia. It can be due to skipping your meals, heavy exercise, or if you are overdosed.