Zoryl-M 1 Tablet

Zoryl-M 1 tablet is an anti-diabetic medicine. It is used to lower the raised blood glucose levels in the blood when it is not being controlled by diet and exercise. It treats Type 2 diabetes.

It contains glimepiride and metformin as their active ingredients. Take the medicine as prescribed by the doctor, after meals. Zoryl-M 1 tablet must not be used in children below 18 years of age.

Do not stop taking the medicine on your own. As, it may result in increased blood sugar level and complications.

Dosage

Overdose

• An overdose of Zoryl-M 1 tablet leads to hypoglycemia (low blood sugar) and lactic acidosis (excessive lactic acid build-up). It results in headache, nausea, vomiting, sleep disturbances, restlessness, impaired alertness and reactions, depression, confusion, dizziness, etc.
• If you experience the symptoms, take glucose or juice or sugar-containing products (sugar candy).
• Contact the doctor or visit the nearest hospital as you may require close monitoring for the next few hours.

Missed a Dose

• A missing dose causes an increase in blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, the fruity smell from breath, etc.
• If you have missed taking a dose of medicine, take it as soon as you remember.
• If it's time for the next dose, skip the missed dose and continue with the regular dose schedule.
• Avoid taking a double dose to compensate for the missed one.

Mode of Action

How Does It Work?

• Zoryl-M 1 tablet controls blood sugar to a greater extent than metformin or glimepiride alone. Glimepiride lowers the blood sugar level increases release of insulin hormone from the pancreas. Insulin carries sugar (glucose) from the blood into the cells.
• Metformin decreases the absorption in the intestine and the production of sugar by the liver.
• Both of the components increases the insulin sensitivity of the body (which allows the cells of the body to use blood glucose more, reducing blood sugar).

Directions for Use

Zoryl-M 1 tablet must be taken as directed by the doctor. Swallow as a whole with a glass of water. Take at a fixed time for optimal results. Avoid consuming more than prescribed by the doctor.

Precautions and Warnings

Pregnancy

Can I take Zoryl-M 1 tablet during pregnancy?

Avoid during pregnancy as it is harmful to the unborn baby. Inform the doctor if you are planning a pregnancy, he might suggest other alternatives.

Breast Feeding

Can I take Zoryl-M 1 tablet while breastfeeding?

Zoryl-M 1 tablet passes into the breast milk in small quantities which might not be harmful to the baby. If you are taking the medicine while breastfeeding, monitor the child for signs of hypoglycemia like excessive sleepiness, poor feeding, fits, difficulty in breathing or decreased body temperature.

Driving

Can I drive after consuming Zoryl-M 1 tablet?

• Zoryl-M 1 tablet causes low blood sugar levels which leads to drowsiness, unconsciousness or confusion. It is dangerous while driving.
• Consult the doctor whether you can drive a car if you have frequent episodes of hypoglycemia.
• Keep a juice or chocolate in the car while driving, in case you start feeling the above symptoms of hypoglycemia, have the juice or chocolate.
• Avoid artificial sweeteners.

Alcohol

Can I consume alcohol while taking Zoryl-M 1 tablet?

• Avoid consuming alcohol during treatment with Zoryl-M 1 tablet.
• Alcohol alters the way the medicine works. Avoid consuming alcohol on an empty stomach. It increases the risk of low blood sugar.
• Excessive consumption of alcohol along with the medicine causes a complication like ketoacidosis.

Other General Warnings

Talk to your doctor if

• You experience hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you experience the symptoms, immediately have sugar or sweet juice. Inform the doctor as you may need a change in the medicine's dose.
• You experience pins-and-needles sensation, numbness and weakness.
• You are undergoing a diagnostic imaging test that involves the injection of iodine.
• You suffer from dehydration due to diarrhoea, vomiting or limited fluid intake.
• You have suffered through trauma.
• You are undergoing surgery.
• You have kidney and liver problems.
• You have a thyroid disorder.
• You suffer from overweight (specific diet restriction may be suggested).

Contraindications

• If you are allergic to metformin, glimepiride or other ingredients of Zoryl-M 1 tablet.
• If you are pregnant or are breastfeeding.
• If you have kidney failure or liver failure.
• If you suffer from metabolic acidosis (excess acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
• If you suffer from dehydration, severe infections, shock and injections containing iodine.
• If you have or had heart, lung failure, the recent incidence of heart attack and shock.
• If you are an alcoholic.

Side effects

• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Loss of appetite
• Metallic taste
• Headache
• Hunger pangs
• Sleepiness
• Restlessness

Interactions

Interactions with other medicines

• Zoryl-M 1 tablet affect the way other medicines work and other medicines affects how Zoryl-M 1 tablet works if taken at the same time.
• Inform the physician about the medicine you are taking, prescribed or non-prescribed herbal medicines, dietary supplements as well as other treatment if you are taking for other disorder.
• Medications like painkillers, medicines for heart diseases, muscle pain, brain-related disorder, antacids like ranitidine, anticoagulants like warfarin, medicine to lower blood cholesterol (fibrates), medicines for a thyroid disorder, antihypertensive medicines, etc.
• Other medicines that must be used with caution are antibiotics like Clarithromycin, oral contraceptives, anti-epileptic medicines like phenytoin, medicines for constipation, water pills, etc.
• You may suffer from low blood sugar if you are already taking other medicines for diabetes like Insulin, Pioglitazone. Caution is advised.

Storage and disposal

• Store at room temperature in a dry place.
• Protect it from direct sunlight and moisture.
• Keep it away from children.

Frequently Asked Questions (FAQs)

Can I stop taking Zoryl-M 1 medicine on my own?

No, you must never stop taking Zoryl-M 1 tablet without consulting the doctor. It results in a sudden rise in blood glucose levels and causes further harm to the kidney and other organs.

What is the use of the Zoryl-M 1 tablet?

Zoryl-M 1 tablet is used to treat Type 2 diabetes mellitus (high blood sugar levels) when blood sugar levels are not controlled by Glimepiride or Metformin along with controlled diet and exercise alone.

My blood sugar falls too often, what is the reason?

• Takes meals on time, fasting, too much alcohol intake, taking alcohol on an empty stomach and taking a double dose.
• If you are taking other medicines mentioned in the drug interaction section, inform the doctor.
• Always keep a juice or sugar candy, in case you experience symptoms of hypoglycemia like headache, irritability, drowsiness, reduced alertness or nausea, have the juice or glucose.
• Avoid taking artificial sweeteners.
• If it occurs too often, inform the doctor as you may need a decrease in the dose of the medicine.

What diet I must follow?

• A diet must be high in fibre, low in fat with adequate protein, carbohydrates, vitamins and minerals.
• Maintain the meal timings and try to have soups and salads.
• Diet must include boiled, steamed or baked food.
• Less use of edible oils (groundnut oil, olive oil), little use of ghee and butter.
• Drink at 8-10 glass of water daily.
• Take fruit or low-calorie high fibre biscuits while travelling.

What I must avoid being a diabetic patient?

• Avoid shopping when you are hungry. You end up buying oily and fried food.
• Avoid overeating.
• Avoid consuming maida, white bread, potato, noodles, corn flakes, poori, biryani, naan, fried rice, etc.
• Stop having daals with ghee, deep-fried pulses.
• Avoid consuming cream soups, carrot juice, deep-fried vegetables, vegetable curries with excess oil.

How does Zoryl M Tablet work?

• Zoryl M Tablet is known to control blood sugar to a greater extent than metformin or glimepiride alone. Glimepiride lowers the blood sugar level increasing release of insulin hormone from the pancreas.
• Insulin moves sugar (glucose) from the blood into the cells.
• Metformin decreases the absorption in the intestine and production of sugar by the liver.
• Both of these components are known to increase the insulin sensitivity of the body (allows the cells of the body to use blood glucose more effectively, reducing blood sugar).

Does Zoryl M Tablet cause low blood sugar level?

Sometimes it may increase the risk of drop in blood sugar level as a side effect. So try to take your meals on time while taking Zoryl M Tablet. However, if you experience any symptoms related to hypoglycaemia such as drowsiness, unconsciousness, confusion etc, immediately drink the juice or eat the chocolate bar. Note that artificial sweeteners are not of any use in such scenarios. Always keep a juice or a bar of chocolate in the car close to you while driving or if you have frequent episodes of hypoglycaemia.