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+91-8877772277Available 7 days a week
10:00 AM – 6:00 PM to support you with urgent concerns and guide you toward the right care.
Leqvio (inclisiran) is a novel injection for managing high cholesterol by targeting PCSK9 protein production. Learn about its mechanism, dosing, effectiveness, and potential side effects.
High cholesterol, medically known as hypercholesterolemia, is a prevalent health concern in India and across the globe. It refers to the condition where there are excessive levels of cholesterol in the blood. Cholesterol, a waxy, fat-like substance, is essential for building healthy cells, producing hormones, and aiding in the absorption of certain vitamins. However, when its levels become too high, particularly low-density lipoprotein (LDL) cholesterol, often termed 'bad' cholesterol, it can lead to serious health issues. This excess LDL cholesterol can accumulate in the arteries, forming plaque, which narrows the passageways and restricts blood flow. This significantly increases the risk of cardiovascular events such as heart attacks and strokes. Unfortunately, high cholesterol often presents no noticeable symptoms, leading many individuals to remain unaware of their condition until a severe complication arises. In some cases, particularly with familial hypercholesterolemia (HeFH), certain physical signs might be present, including gray-white deposits around the corneas (corneal arcus), fatty deposits on the skin (xanthomas) on areas like knees, elbows, and buttocks, and cholesterol deposits around the eyelids (xanthelasmas).
Leqvio, with its active ingredient inclisiran, represents a novel therapeutic approach to managing high cholesterol. Unlike traditional cholesterol-lowering medications, Leqvio targets the root cause of elevated LDL cholesterol by focusing on the PCSK9 protein. The liver naturally produces the PCSK9 protein, which plays a crucial role in regulating LDL cholesterol levels. PCSK9 binds to LDL receptors on the surface of liver cells, marking them for degradation. This process reduces the number of LDL receptors available to remove LDL cholesterol from the bloodstream, thereby increasing its levels. Leqvio works by specifically decreasing the production of PCSK9 protein by the liver. By inhibiting PCSK9, Leqvio allows more LDL receptors to remain on the liver cell surface, leading to a more efficient removal of LDL cholesterol from the blood and a significant reduction in overall LDL cholesterol levels.
Leqvio is administered as a subcutaneous injection, meaning it is injected just under the skin. This is typically performed in a healthcare professional's office. The initial treatment regimen involves two doses administered three months apart. Following these initial doses, patients receive a single injection every six months. This infrequent dosing schedule is a significant advantage, offering convenience and potentially improving adherence compared to daily oral medications or more frequent injections. Leqvio is available in a prefilled syringe containing 284 milligrams (mg) of inclisiran in 1.5 milliliters (mL) of solution, with each syringe providing a single dose.
Leqvio begins to work shortly after the first dose. Clinical studies have demonstrated that some individuals experience a reduction in their cholesterol levels as early as two weeks after initiating treatment. The sustained effect of the six-month dosing schedule helps maintain lowered cholesterol levels over the long term.
It is important to note that while Leqvio effectively lowers LDL cholesterol, its impact on reducing the risk of cardiovascular events like heart attacks and strokes is still under investigation. Some existing cholesterol-lowering drugs have proven benefits in reducing these risks. Therefore, doctors may prescribe Leqvio in conjunction with other cholesterol-lowering medications to provide comprehensive protection against cardiovascular complications. Leqvio is a brand-name medication, and a generic version is not currently available.
Like all medications, Leqvio can cause side effects, ranging from mild to serious. Common side effects may include injection site reactions such as redness, pain, or itching. Less common but more serious side effects can occur. It is crucial to be aware of these potential reactions. If you experience any concerning symptoms, such as signs of a severe allergic reaction (swelling of the face, lips, tongue, or throat; difficulty breathing; severe rash), you should seek immediate medical attention by calling emergency services (like 108 or 112 in India) or going to the nearest hospital. Your doctor or pharmacist can provide a comprehensive list of potential side effects and discuss how to manage them.
If you have been diagnosed with high cholesterol or are at risk for cardiovascular disease, it is essential to consult with your doctor. They can assess your individual health status, discuss treatment options, including Leqvio, and monitor your progress. Prompt medical consultation is also necessary if you experience any unusual or severe symptoms that you suspect might be related to your cholesterol levels or medication.
The primary benefit of Leqvio is its ability to significantly lower LDL ('bad') cholesterol levels through a novel mechanism of action that reduces PCSK9 protein production. Its infrequent dosing schedule (every six months after initial doses) also offers convenience.
No, Leqvio is not a daily pill. It is administered as a subcutaneous injection, with the first two doses given three months apart, followed by injections every six months.
While Leqvio effectively lowers cholesterol, its role in directly preventing heart attacks and strokes is still being studied. Doctors may prescribe it alongside other medications that have proven benefits in reducing cardiovascular event risks.
If you miss a scheduled Leqvio injection, contact your doctor's office immediately to reschedule. Do not try to self-administer the dose or adjust the schedule without medical guidance.
While Leqvio is a powerful medication, maintaining a heart-healthy diet remains crucial for managing cholesterol. Your doctor or a registered dietitian can provide personalized dietary advice, focusing on reducing saturated and trans fats, increasing fiber intake, and incorporating more fruits, vegetables, and whole grains.
This section adds practical context and preventive advice to help readers make informed healthcare decisions. It is important to verify symptoms early, consult qualified doctors, and avoid self-medication for persistent health issues.
Maintaining healthy routines, following prescribed treatment plans, and attending regular checkups can improve outcomes. If symptoms worsen or red-flag signs appear, immediate medical evaluation is recommended.
Track symptoms and duration.
Follow diagnosis and treatment from a licensed practitioner.
Review medication side effects with your doctor.
Seek urgent care for severe warning signs.
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