Napra D 250 Tablet

Napra D 250 tablet is a combination medicine that is used to treat migraine headaches and inflammatory conditions of the joints. It contains naproxen, which is an anti-inflammatory medicine and domperidone, which is an anti-emetic agent. Naproxen works by blocking the production of substances that cause inflammation.

This helps to reduce pain, swelling and stiffness in the joints. Domperidone works by blocking the signals that cause nausea and vomiting. Napra D 250 tablet should be taken as prescribed by your doctor.

It is important to take the medicine on time to get the best results. Do not stop taking the medicine without talking to your doctor, even if you feel better. Avoid taking this medicine if you have a heart rhythm problem or a history of ulcers due to painkillers.

Long-term treatment with this medicine can affect your liver and kidneys. Other medications like Naxdom 250 tablet , Naprosyn D 250mg tablet , Macprox Dp 250mg tablet , Xenadom 250mg tablet and Domstal Np 250mg tablet also include naproxen and domperidone. Before using this medicine, inform the doctor if you are pregnant, planning a pregnancy or breastfeeding and about your detailed medical history.

This medicine should not be used in children below 5 years of age.

Dosage

Overdose

Symptoms of overdose of Napra D 250 tablet are nausea, vomiting, stomach pain, diarrhoea, dizziness, sleepiness, excitement, and irritation. If you experience any of the symptoms or think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

Missing a dose of Napra D 250 tablet may reduce the effectiveness of the treatment. If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.

Mode of Action

How Does It Work?

• Napra D 250 tablet contains a combination of naproxen and domperidone as active substances.
• Naproxen belongs to a group of medicine that blocks the effect of inflammatory chemicals. So, the symptoms like redness, pain, inflammation, and swelling improve gradually.
• Domperidone is used to control nausea and vomiting. It prevents food from coming back up in the oesophagus (food pipe), which may occur due to stomach irritation caused by naproxen and other painkillers and in migraine attacks.

Directions for Use

• Napra D 250 tablet should be taken as directed by your doctor.
• Swallow it whole with a glass of water.
• Do not cut, break or chew the medicine.
• It would be best if you took it at a fixed time for optimal results.
• Do not consume more than the dose prescribed by your doctor.

Precautions and Warnings

Pregnancy

Can I take Napra D 250 tablet during pregnancy?

Napra D 250 tablet should be avoided during pregnancy.

Breast Feeding

Can I take Napra D 250 tablet while breastfeeding?

Napra D 250 tablet passes into human milk. Thus, either medicine or breastfeeding should be discontinued.

Driving

Can I drive if I have consumed Napra D 250 tablet?

Napra D 250 tablet may cause dizziness, drowsiness, fatigue, and vision problems. Therefore, you should avoid driving if you do not feel well or are unable to be alert.

Alcohol

Can I consume alcohol with Napra D 250 tablet?

You should not consume alcohol while on treatment with Napra D 250 tablet, as the chances of stomach ulceration and bleeding increase. Thus, you should avoid consuming alcohol while on treatment with this medicine.

Other General Warnings

Talk to your doctor if

• You have any stomach and intestinal diseases.
• You smoke or consume alcohol regularly.
• You are above 65 years of age.
• You had or have problems with your heart, liver, or kidney.
• You have diabetes or high blood pressure or high cholesterol.
• You have asthma or any problems with your breathing.
• You are planning to have a baby, as Naproxen may interfere with female fertility.
• You are using other medicines that may cause bleeding and ulcers in the stomach.
• You have to undergo any blood or urine tests.
• You are taking medicines or painkillers for headaches too often.
• You are above 12 years of age with a body weight below 35 kgs.
• You are taking apomorphine.
• You have developed an allergy or skin rash after taking this medicine.
• You have an autoimmune disorder called systemic lupus erythematosus or any tissue disorder or any blood clotting issues.
• You have Parkinson’s disease, asthma, colitis, or Crohn's disease.

Contraindications

• If you are allergic to naproxen, domperidone, or any other ingredients of Napra D 250 tablet.
• If you have an allergy to painkillers like aspirin or ibuprofen. If you are not sure what these medicines are, please confirm with your doctor.
• If you have a history of ulcers or bleeding.
• If you have any problems with your heart, liver, or kidney.
• If you're pregnant or think you may be pregnant or breastfeeding.
• If you have a pituitary gland tumour that releases an excess of prolactin hormone (prolactinoma).
• If you have an obstruction, blockage, or perforation (tear) in the intestine or any part of the gut.
• If you have any condition due to which there is a salt imbalance in your body (low levels of potassium or magnesium or high level of potassium).

Side effects

• Headache
• Dizziness
• Tiredness
• Sleepiness
• Rashes

Interactions

Interactions with other medicines

• Some medicines can affect the way Napra D 250 tablet works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
• You may experience abnormal heart rhythm when taking this medicine along with medicines like amiodarone, used in abnormal heart rhythm, particular care should be taken when using medicines like haloperidol and escitalopram used in psychiatric illness, antibiotics such as erythromycin, antifungals such as ketoconazole, lumefantrine used in malaria, cisapride used for gastric problems, mizolastine used in allergy and anticancer such as vandetanib.
• Concomitant use of this medicine along with diltiazem and verapamil used for the treatment of heart problems is not recommended.
• It decreases the effectiveness of atenolol and water pills such as furosemide used to treat high blood pressure.
• Maintain a minimum gap of 10-12 days between the use of this medicine and mifepristone.
• The chances of kidney damage increase if Napra D 250 tablet is taken along with cyclosporine and tacrolimus which are medicines used to prevent organ rejection.
• The chances of stomach ulcers and bleeding increase if used along with steroids like prednisone, painkillers, blood thinners like warfarin, and bisphosphonates used to treat weakened bone.
• You may experience fits and convulsions if taken along with antibiotics such as ciprofloxacin and ofloxacin.
• The side effects related to blood increase if taken along with zidovudine used in the treatment of HIV infection.
• You should take this medicine at least 1 hour before or 4 to 6 hours after cholestyramine used in the treatment of cholesterol problems.
• Other medicines like phenytoin, lithium, methotrexate, digoxin, probenecid, gliclazide, and sulfamethoxazole should be used cautiously along with Napra D 250 tablet.

Storage and disposal

• Store Napra D 250 tablet below 25°C protected from moisture, sunlight, and heat.
• Keep this medicine away from children and pets.

Frequently Asked Questions (FAQs)

I am having a heart problem, can I take Napra D 250 tablet?

No, you should not take Napra D 250 tablet as it is associated with the development of abnormal heart rhythms. Discuss with your doctor beforehand if you are prescribed this medicine. Your doctor may advise frequent follow-up and regular heart function monitoring.

Can Napra D 250 tablet be taken on an empty stomach?

You should preferably take Napra D 250 tablet after meals, to avoid stomach discomforts.

Can I take Napra D 250 tablet with other pain killers?

No, you should not take Napra D 250 tablet with other pain killers as it increases the chances of having side effects.

How frequently can we take Napra D 250 tablet?

Your treating doctor decides the duration and frequency of Napra D 250 tablet after accessing the condition. It varies among individuals depending upon their condition. Do not self medicate and take it as prescribed by your doctor.

Can I take Dolo 650 along with Napra D 250 tablet?

Dolo 650 is an analgesic medicine. It contains paracetamol which is used to reduce pain and fever. Dolo 650 or any pain-reducing medicine should not be taken along with this medicine as it can aggravate the side effects. Consult your doctor for more information on the safety of concomitant use of these medicines.

Does Napra D 250 tablet affect kidneys?

Yes, it can upon long term or frequent use, as components of this medicine work by inhibiting the production of a chemical called prostaglandin. Prostaglandin is associated with maintaining blood flow and filtration rate of kidneys and inhibiting the production of this chemical can affect kidney function. Patients with kidney problems should be extra cautious and you should avoid frequent use of this medicine.

What is Napra D 250 used for?

• Napra D 250 tablet is used to relieve pain, swelling and discomfort associated with different forms of arthritis and other conditions.
• It is also used to prevent migraine (intense headaches with nausea, vomiting and sensitivity to light and sound).

Is Napra D 250 a painkiller medicine?

Yes, Napra D 250 tablet is a painkiller medicine that is used to relieve pain, swelling and discomfort in arthritis and other conditions like migraine.