Napra D 500 Tablet

Napra D 500 mg tablet contains naproxen and domperidone. Naproxen is an anti-inflammatory, while domperidone is an anti-emetic agent. It is used to treat inflammation (pain and swelling) of the joints like rheumatoid arthritis and other forms of arthritis.

It is used to treat migraine headaches. Napra d 500 works by blocking the effect of inflammation-inducing substances, producing relief in symptoms and controlling nausea and vomiting. Before starting this medicine, inform your doctor about all your ongoing medication.

Naxdom 500 tablet also contain naproxen and domperidone.

Dosage

Overdose

Symptoms of overdose are nausea, vomiting, stomach pain, diarrhoea, dizziness, sleepiness, excitement, irritation, unconsciousness, etc. You experience the symptoms or have taken too much of the medicine, contact the doctor immediately or visit the nearest hospital.

Missed a Dose

Missing a dose reduce the effectiveness of the treatment. If you have missed taking a dose, take it as soon as you remember it. If it is time for the next dose, skip the missed dose. Avoiding taking a double dose to compensate for the missed dose.

Mode of Action

How Does It Work?

Naproxen and Domperidone are the active ingredients in Napra-D-500 Tablet. Naproxen works by preventing the formation of certain chemicals in the body that cause pain and swelling. Domperidone works by preventing nausea caused by migraines by blocking the action of a chemical in the brain.

Directions for Use

Take as directed by the doctor. Swallow as a whole with a glass of water. Do not cut, break or chew the medicine. Take at a fixed time for optimal results and must not consume it more than that prescribed by the doctor.

Precautions and Warnings

Pregnancy

Can I take Napra D 500mg medicine during pregnancy?

The medicine may cause harmful effects in the unborn baby and leads to malformations and impair the formation of kidney and heart. The medicine increases the risk of bleeding and even delay labour. Thus, avoid during pregnancy.

Breast Feeding

Can I take Napra D 500mg medicine while breastfeeding?

It passes into human milk and harms the newborn baby. Thus, either medicine or breastfeeding must be discontinued.

Driving

Can I drive after consuming Napra D 500mg Tablet?

The medicine may cause dizziness, drowsiness, fatigue and vision problems. Therefore, avoid driving if you feel unwell or unable to be alert.

Alcohol

Can I consume alcohol while taking Napra D 500mg medicine?

Avoid consuming alcohol while on treatment, as the chances of stomach ulceration and bleeding increase. Thus, avoid consuming alcohol while on treatment with the medicine.

Other General Warnings

Talk to your doctor if

• You have other stomach and intestinal diseases.
• You smoke or consume alcohol.
• You are above 65 years of age.
• You had or have problems with the heart, liver or kidney.
• You have diabetes or high blood pressure or cholesterol.
• You have asthma or problems with breathing.
• You are planning for a baby, as Naproxen may interfere with female fertility.
• You are using other medicines that cause bleeding and ulcers in the stomach.
• You have to undergo blood or urine tests.
• You are taking medicines or painkillers for headaches.
• You are above 12 years of age with a body weight below 35 kgs.
• You are taking Apomorphine.
• You have developed an allergy or skin rash after taking the medicine.
• You have an autoimmune disorder called systemic lupus erythematosus, tissue disorder, or blood clotting issues.
• The medicine aggravates the symptoms of Parkinson’s disease, asthma, colitis and Crohn's disease. Thus, use it with caution.
• It must not be used in children below 5 years of age.

Contraindications

• If you are allergic to Naproxen, Domperidone or other ingredients of Napra D 500mg Tablet.
• If you have an ulcer or bleeding.
• If you have problems with the heart, liver and kidney.
• If you having an allergy to painkillers like aspirin or Ibuprofen.
• If you have stomach, intestinal ulcers and bleeding from ulcers.
• If you're pregnant or may be pregnant or breastfeeding.
• If you have a pituitary gland tumour that releases an excess of prolactin hormone (prolactinoma).
• If you have an obstruction, blockage or perforation (tear) in the intestine or part of the gut.
• If you have a condition due to which there is a salt imbalance in the body (low levels of potassium or magnesium or high level of potassium).

Side effects

• Headache
• Dizziness
• Fatigue
• Dry mouth
• Skin rash & itching
• Swelling
• Confusion
• Palpitations
• Ringing in the ear
• Visual disturbances

Interactions

Interactions with other medicines

• Certain medicines affect the way Napra D 500mg tablet works or Napra D 500mg tablet itself affects the action of other medicines taken at the same time.
• Inform the physician about the medicines, supplements or herbals you are taking or might take to avoid possible interaction.
• Taking medicines like Amiodarone (used in abnormal heart rhythm), Haloperidol, Escitalopram (used in psychiatric illness), antibiotics like Erythromycin, antifungals like Ketoconazole and Lumefantrine used in malaria, Cisapride used for gastric problems, Mizolastine used in allergy and anticancer like Vandetanib.
• Concomitant use of the medicine along with Diltiazem, Verapamil used for the treatment of heart problems is not recommended.
• Napra D 500 mg tablet decreases the effectiveness of Atenolol and water pills like Furosemide used to treat high blood pressure.
• Maintain a minimum gap of 10-12 days between the use of the medicine and mifepristone, as the former reduces the effectiveness of the latter.
• Kidney damage increases if Napra D 500mg medicine is taken along with Cyclosporine and Tacrolimus, medicines used to prevent organ rejection.
• Stomach ulcers and bleeding increase with the use of steroids like prednisone, painkillers, and blood thinners like Warfarin and Bisphosphonates used to treat weakened bone.
• You may experience fits and convulsions if taken along with antibiotics like Ciprofloxacin and Ofloxacin.
• Side effects of blood increase if taken along with Zidovudine used in the treatment of HIV infection.
• You must take the medicine at least 1 hour before or 4 to 6 hours after Cholestyramine is used in the treatment of cholesterol problems.
• Other medicines like Phenytoin, Lithium, Methotrexate, Digoxin Probenecid, Gliclazide and Sulfamethoxazole must be used cautiously along with Napra D 500mg Tablet.

Storage and disposal

• Store the medicine below 25°C protected from moisture, sunlight and heat.
• Keep it away from children and pets.
• Avoid flushing the expired medicine in the toilet or throw them in household waste or drain.

Frequently Asked Questions (FAQs)

I am suffering from a heart problem, can I take Napra D 500mg medicine?

No, you must not take Napra d 500 as it is associated with the development of abnormal heart rhythms. Discuss with the doctor beforehand if you are prescribed the medicine. The doctor may advise frequent follow-up and regular heart function monitoring.

Can Napra d 500 be consumed on an empty stomach?

Napra d 500 must preferably be taken after meals, to avoid stomach discomforts.

Can Napra D 500mg be taken with other pain killers?

No, you should not take Napra d 500 with other pain killers as it increases the chances of having side effects.

How frequently the Napra D 500mg medicine can be taken?

The doctor decides the duration and frequency of medicine after accessing the condition. It varies among individuals depending upon the condition. Do not self medicate and take it as prescribed by the doctor.

Can I take Dolo 650 along with Napra D 500mg medicine?

Dolo 650 is an analgesic medicine. It contains paracetamol that reduces pain and fever. Dolo 650 or pain-reducing medicine must not be taken along with the medicine as it aggravates the side effects. Consult the doctor for more information on the safety of concomitant use of these medicines.

Does the medicine affect kidneys?

Yes, for long term or frequent use, as components of the medicine inhibits the production of a chemical called prostaglandin. Prostaglandin maintains the blood flow and filtration rate of kidneys and inhibits the production of the chemical that affects kidney function. Patients with kidney problems must be extra cautious and avoid frequent use of the medicine.

Can I take Napra D for a longer duration?

No, it should not be used for more than recommended duration. Long term use causes unwanted side effects.

What is the composition of Napra D?

The composition of Napra D includes- naproxen and domperidone.

Can I take Napra D daily?

Yes, you should take Napra D daily, but for the prescribed duration only. Do not exceed the maximum daily doses and treatment durations recommended.

How does Napra D work?

Napra D contains naproxen and domperidone as its active ingredients. Naproxen is an anti-inflammatory while Domperidone is an anti-emetic agent. This medicine works by the collective action of these two ingredients. It blocks the effect of inflammation-inducing substances and produce relief in symptoms and controls nausea and vomiting.